Published Research

Testosterone References

Carter HB, Pearson JD, Metter EJ, Chan DW, Andres R, Fozard JL, Rosner W, Walsh PC. Prostate 1995 Jul;27(1):25-31. Longitudinal evaluation of serum androgen levels in men with and without prostate cancer.

There was no correlation of serum testosterone or free testosterone with prostate cancer 

Cooper CS, MacIndoe JH, Perry PJ, Yates WR, Williams RD. J Urol 1996 Aug;156(2 Pt 1):438-41; discussion 441-2 The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men.

There was no increase in PSA when supplemental testosterone was used.

References for Vitamin C

Podmore ID, Griffiths HR, Herbert KE, et al. Vitamin C exhibits pro-oxidant properties. Nature 1998;392:559.

Jenner A, England TG, Aruoma OI, Halliwell B. Measurement of oxidative DNA damage by gas chromatography_mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Biochem J 1998;331:365-369.

Chen LH. An increase in vitamin E requirement induced by high supplementation of vitamin C in rats. Am J Clin Nutr, 1981 Jun;34(6):1036-1041.

Gey KF. Vitamins E plus C and interacting conutrients required for optimal health. Biofactors 1998;7(12):113-174.]

Jacques, P.F., et al. 1997. Long-term vitamin C supplement use and prevalence of early age-related lens opacities. American Journal of Clinical Nutrition 66(October):911.

Mares-Perlman, J.A. Contribution of epidemiology to understanding relations of diet to age-related cataract. American Journal of Clinical Nutrition 66(October):739.

Kristenson M et al. Antioxidant state and mortality from coronary artery disease in Lithuanian and Swedish men. British Medical Journal. March 1, 1997; 314:629-633.

Nyyssonen K et al. Vitamin C deficiency and risk of myocardial infarction. British Medical Journal. March 1, 1997; 314:634-8.

Enstrom EE, Kanim LE, Klein MA: Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3(3):194-202.

USDA Nutritive Value of american Foods in Common Units, Agrigulture Handbook No 456.

Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers

Mc Alindon ME et al

United Kingdom Gut (United Kingdom), 1996, 38/4 (518-524

An experimental study on the protection against reperfusion myocardial ischemia by using large doses of vitamin C

CHIN. J. CARDIOL. (China), 1994, 22/1 (52-54+80)

Hemodynamic effects of delayed initiation of antioxidant therapy (beginning two hours after burn) in extensive third-degree burns

Tanaka H et al.

Journal of Burn Care and Rehabilitation (USA), 1995, 16/6 (610-615

An experimental study on the protection against reperfusion myocardial ischemia by using large doses of vitamin C

CHIN. J. CARDIOL. (China), 1994, 22/1 (52-54+80)

Vitamin C as a radioprotector against iodine-131 in vivo

J. NUCL. MED. (USA), 1993, 34/4 (637-640)

Narra VR et al.

Reduced fluid volume requirement for resuscitation of third-degree burns with high-dose vitamin C

J. BURN CARE REHABIL. (USA), 1991, 12/6 (525-532)

Tanaka H et al.

Effects of dietary vitamin C and E supplementation on the copper mediated oxidation of HDL and on HDL mediated cholesterol efflux.

Rifici VA; Khachadurian AK Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903-0019, USA. Atherosclerosis (IRELAND) Nov 15 1996, 127 (1) p19-26

Possible prevention of postangioplasty restenosis by ascorbic acid.

Tomoda H; Yoshitake M; Morimoto K; Aoki N Department of Cardiology, Tokai University, Kanagawa, Japan. Am J Cardiol (UNITED STATES) Dec 1 1996, 78 (11) p1284-6

Vitamin C and cardiovascular disease: a systematic review.

Ness AR; Powles JW; Khaw KT Institute of Public Health, University Forvie Site, Cambridge, UK. J Cardiovasc Risk (ENGLAND) Dec 1996, 3 (6) p513-21

Vitamin C and the common cold

Chalmers T, American Journal of Medicine 1975;58:532-6

Vitamin C intake and susceptibility to the common cold.

Hemila H Department of Public Health, University of Helsinki, Finland. Br J Nutr (ENGLAND) Jan 1997, 77 (1) p59-72

Antioxidant status and neovascular age-related macular degeneration

ARCH. OPHTHALMOL. (USA), 1993, 111/1 (104-109)

West S et al.

Vitamin C status and blood pressure.

J Hypertens (ENGLAND) Apr 1996, 14 (4) p503-8

Ness AR et al.

Dietary vitamin C, beta-carotene and 30-year risk of stroke: Results from the western electric study.

Daviglus M.L.; Orencia A.J.; Dyer A.R.; Liu K.; Morris D.K.; Persky V.; Chavez N.; Goldberg J.; Drum M.; Shekelle R.B.; Stamler J. USA Neuroepidemiology (Switzerland), 1997, 16/2 (69-77)

Human Growth Hormone

 

Savine R, Sonksen PH. Related Articles 
Is the somatopause an indication for growth hormone replacement?
J Endocrinol Invest. 1999;22(5 Suppl):142-9. Review.
PMID: 10442584; UI: 99369188

Aleman A, Verhaar HJ, De Haan EH, De Vries WR, Samson MM, Drent ML, Van der Veen EA, Koppeschaar HP. Related Articles 
Insulin-like growth factor-I and cognitive function in healthy older men.
J Clin Endocrinol Metab. 1999 Feb;84(2):471-5.
PMID: 10022403; UI: 99145001

Sugimoto T, Nakaoka D, Nasu M, Kanzawa M, Sugishita T, Chihara K. Related Articles 
Effect of recombinant human growth hormone in elderly osteoporotic women.
Clin Endocrinol (Oxf). 1999 Dec;51(6):715-724.
[Record as supplied by publisher]
PMID: 10619976

Baum HB, Biller BM, Finkelstein JS, Cannistraro KB, Oppenhein DS, Schoenfeld DA, Michel TH, Wittink H, Klibanski A. Related Articles 
Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial.
Ann Intern Med. 1996 Dec 1;125(11):883-90.
PMID: 8967668; UI: 97067809

Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency.
J Clin Endocrinol Metab. 1999 Apr;84(4):1329-33.
PMID: 10199774; UI: 99213866

Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults.
J Clin Endocrinol Metab. 1999 Feb;84(2):453-7.
PMID: 10022400; UI: 99144998

Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency.
J Clin Endocrinol Metab. 1999 Apr;84(4):1329-33.
PMID: 10199774; UI: 99213866

The role of growth hormone and insulin-like growth factor I in the regulation of apoptosis.
Growth Horm IGF Res. 1999 Apr;9 Suppl A:125-8. Review. No abstract available.
PMID: 10429896; UI: 99358544

Rudman, D et al. Effects of Human Growth Hormone in Men over 60 years old. New England Journal of Medicine. 323:1-6, 1990.

Dr. Rudman's article in the prestigious New England Journal of Medicine concluded that Human Growth Hormone replacement therapy reversed the changes of aging 10-20 years.

Cittadini A et al. American Journal of Physiology 1994 Aug;267(2 Pt 1):E219-25

Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement. 

Part of the weakness and eventual debility that is associated with growth hormone deficiency is poor cardiac function. Replacing growth hormone will improve heart function.

 O'Halloran DJ, Tsatsoulis A, Whitehouse RW et al. Increased Bone Density after Growth Hormone (HGH) Therapy in Adults with Isolated HGH Deficiency. J Clin Endo Metab 1993;76:1344-48.

Growth hormone replacement is the only known treatment which will actually cause new bone growth, decreasing osteoporosis and the risk of fracture. 

Salomon F, Cuneo RC, Hesp R et al. The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency. New England Journal of Medicine 1989;321:1797-1803.

Bengtsson BA. The Consequences of Growth Hormone Deficiency in Adults. Acta Endocrinologica 1993;128 (Suppl 2):2-5.

Cuneo RC, Salomon F, Wiles CM et al. Growth Hormone Treatment in Growth Hormone Deficient Adults. II. Effects on Exercise Performance. Journal of Applied Physiology 1991;70:695-700.

O'Halloran DJ, Tsatsoulis A, Whitehouse RW et al. Increased Bone Density after Recombinant Human Growth Hormone (GH) Therapy in Adults with Isolated GH Deficiency. Journal of Clinical Endocrinology and Metabolism 1993;76:1344-1348.

McGauley GA, Cuneo RC, Salomon F et al. Psychological Well-Being Before and After Growth Hormone Treatment in Adults with Growth Hormone Deficiency. Hormone Research 1990;33 (suppl 4):52-54.

Bengtsson BA, Eden S, Lonn L et al. Treatment of Adults with Growth Hormone (GH) Deficiency with Recombinant Human GH. Journal of Clinical Endocrinology and Metabolism 1993;76;309-317.

Johnston DG, Bengtsson BA. Workshop Report: the Effects of Growth Hormone and Growth Hormone Deficiency on Lipids and the Cardiovascular System. Acta Endocrinologica 1993;128 (Suppl 2): 69-70.

Amato G, Carella C, Fazio S et al. Body Composition, Bone Metabolism, and Heart Structure and Function in Growth Hormone (GH)-Deficient Adults Before and After GH Replacement Therapy at Low Doses. Journal of Clinical Endocrinology and Metabolism 1993;77:1671-1676.

 Lieberman SA, Hoffman AR. Clin Geriatr Med 1997 Nov;13(4):671-84. The somatopause: should growth hormone deficiency in older people Be treated?

Rosen T, Johannsson G, Johansson JO, Bengtsson BA . Horm Res 1995;43(1-3):93-9. Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment. A review paper.

Replacement therapy with grown hormone is safe without any serious side effects

 Johannsson G, Rosen T, Bosaeus I, Sjostrom L, Bengtsson BA. J Clin Endocrinol Metab 1996 Aug;81(8):2865-73. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency.

In 2 years of treatment with growth hormone, bone density increases 4%

There is a mountain of evidence of the benefits of growth hormone replacement to youthful levels. There is approximately 20 year experience in children receiving growth hormone that demonstrates that no serious medical complications are seen.